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Allele : Gt(ROSA)26Sor<tm3(CAG-YAP1*,-lacZ)Jmao> gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Junhao Mao
Primary Identifier  MGI:6763056 Allele Type  Targeted
Attribute String  Conditional ready, Constitutively active, Epitope tag, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  The following elements were inserted into the locus: the CAG promoter, a loxP site, a neomycin resistance gene cassette, a STOP cassette (four poly(A) signal sequences), a second loxP site, a mutated human yes-associated protein 1 cDNA (where all five serine codons were changed to alanine to create a constitutively active form of the encoded peptide) with 5' in-frame FLAG tag and NLS coding sequence, an IRES, and the lacZ beta galactosidase reporter gene. Only after cre-mediated removal of the neo-STOP cassette will this locus express the YAP1 and lacZ genes.
  • mutations:
  • Insertion
  • synonyms:
  • nls-YAP5SA<KI>,
  • nls-YAP5SA<KI>,
  • R26-YAP5SA-NLS,
  • R26-YAP5SA-NLS
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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