| Primary Identifier | MGI:6763106 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Trp53 |
| Transmission | Germline | Strain of Origin | (C57BL/6NTac x 129S6/SvEvTac)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An A-to-G point mutation (c.707A>G) was engineered in exon 7 to change asparagine codon 236 to a serine codon (p.N236S). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 11 was removed through subsequent cre-mediated recombination. The mutation is found in some human tumors and some tumorigenic mouse cell lines. |
