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Allele : Apoe<tm2.2Hol> apolipoprotein E; targeted mutation 2.2, David M Holtzman
Primary Identifier  MGI:6780677 Allele Type  Targeted
Attribute String  Null/knockout Gene  Apoe
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting construct replaced the coding sequence with a loxP site, FRT-flanked neomycin resistance cassette, the human coding sequence for isoform 3 (E3F) with signal peptide, an F3 flanked puromycin resistance cassette, loxP site, and human GH polyadenylation sequence. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Apoe<EKO>,
  • Apoe<EKO>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

4 Publication categories

Trail: Allele




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