| First Author | He Y | Year | 2021 |
| Journal | Immunology | Volume | 164 |
| Issue | 1 | Pages | 190-206 |
| PubMed ID | 33987830 | Mgi Jnum | J:311878 |
| Mgi Id | MGI:6752478 | Doi | 10.1111/imm.13365 |
| Citation | He Y, et al. (2021) Gm40600 promotes CD4(+) T-cell responses by interacting with Ahnak. Immunology 164(1):190-206 |
| abstractText | It is important to characterize novel proteins involved in T- and B-cell responses. Our previous study demonstrated that a novel protein, Mus musculus Gm40600, reduced the proliferation of Mus musculus plasmablast (PB)-like SP 2/0 cells and B-cell responses induced in vitro by LPS. In the present study, we revealed that Gm40600 directly promoted CD4(+) T-cell responses to indirectly up-regulate B-cell responses. Importantly, we found that CD4(+) T-cell responses, including T-cell activation and differentiation and cytokine production, were increased in Gm40600 transgenic (Tg) mice and were reduced in Gm40600 knockout (KO) mice. Finally, we demonstrated that Gm40600 promoted the Ahnak-mediated calcium signalling pathway by interacting with Ahnak to maintain a cytoplasmic lateral location of Ahnak in CD4(+) T cells. Collectively, our data suggest that Gm40600 promotes CD4(+) T-cell activation to up-regulate the B-cell response via interacting with Ahnak to promote the calcium signalling pathway. The results suggest that targeting Gm40600 may be a means to control CD4(+) T-cell-related diseases. |
