| First Author | Turovsky L | Year | 2024 |
| Journal | Cell Death Dis | Volume | 15 |
| Issue | 2 | Pages | 174 |
| PubMed ID | 38409173 | Mgi Jnum | J:345791 |
| Mgi Id | MGI:7611038 | Doi | 10.1038/s41419-024-06554-4 |
| Citation | Turovsky L, et al. (2024) miR-184 represses beta-catenin and behaves as a skin tumor suppressor. Cell Death Dis 15(2):174 |
| abstractText | miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of beta-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of beta-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy. |
