| Primary Identifier | MGI:6761816 | Allele Type | Endonuclease-mediated |
| Attribute String | Not Specified | Gene | Itpr1 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology was used to design guide RNAs that disrupt exons 59 and 62 of mouse Itpr1. Three founder mice with a deletion in exon 59 at a high mosaic rate died soon after birth for unknown reasons. Another mouse line with a seven-base pair deletion (c.8238_8244delAGCCGGC) in the last exon of Itpr1 which resulted in a frameshift and readthrough mutation was established and used for the study. |
