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Allele : Tg(HTT*131Q)BACXwy transgene insertion BAC, X William Yang
Primary Identifier  MGI:6864447 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(HTT*131Q)BACXwy
Strain of Origin  FVB/NJ Is Recombinase  false
Is Wild Type  false
molecularNote  The 240 kb human bacterial artificial chromosome (BAC) RP11-866L6, containing the entire 170 kb human Huntingtin (HTT) genomic locus and approximately 20 kb of 5' and 50 kb of 3' flanking sequences, was modified by replacing the human mutant mHTT exon 1 sequence (containing about 120 CAG repeats followed by one CAA, 8 CAGs and another CAA-CAG encoding a total of about 131 glutamine repeats). Founder line BAC-CAG contains 2 tandem copies of the transgene. mHTT repeat sizing and sequencing confirmed an uninterrupted CAG repeat size of about 120, with total polyQ repeat sequence of 131.
  • mutations:
  • Insertion
  • synonyms:
  • BAC-CAG,
  • BAC-CAG
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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