Primary Identifier | MGI:7266849 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Rbm20 |
Strain of Origin | C57BL/6NJ | Is Recombinase | false |
Is Wild Type | false |
molecularNote | CRISPR/Cas9 technology generated an A to G change resulting in a serine to glycine substitution at amino acid 639 (p.S639G) in the RS domain. This is equivalent to the human S637G mutation seen in patients with severe dilated cardiomyopathy. |