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Allele : Panx1<em1Ravi> pannexin 1; endonuclease-mediated mutation 1, Kodi S Ravichandran
Primary Identifier  MGI:6888006 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Panx1
Strain of Origin  C57BL/6 x SJL Is Recombinase  false
Is Wild Type  false
molecularNote  Using an sgRNA (targeting CCACTTCAAGTACCCAATCG) and an ssODN template (GTGAAGAGAGGCTGAAGTAATAGCTCAAGTAGATACATGCCAACAGTATAACCACAAATGTCACCAGCCGGCAGCTAATGTATTTCATGATTAAATGACTCGCGTTCTTTTTTGTCTTCAAGTACTGCTCAACGATTGGGTACTTGAAGTGGCTTTCAGATATCTCCCACAGACTGAAAAACAAAGCAAATAAAAATAAT) with CRISPR/Cas9 technology, serine codon 205 (TCT) was changed to alanine (GCG)(p.S205A). This mutation renders residue 205 non-phosphorylatable.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Panx1<S205A>,
  • Panx1<S205A>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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2 Publication categories





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