| Primary Identifier | MGI:6886084 | Allele Type | Targeted |
| Attribute String | Constitutively active | Gene | Trpv1 |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A G>A mutation (c.1690G>A) was engineered to change glycine codon 564 in exon 11 to a serine codon (p.G564S) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 12. The neo cassette was removed through subsequent cre-mediated recombination. The mutation is a gain-of-function mutation leading to a severe reduction in capsaicin and noxious heat sensitivity. |
