| First Author | Chen X | Year | 2021 |
| Journal | J Immunol | Volume | 206 |
| Issue | 8 | Pages | 1832-1843 |
| PubMed ID | 33789983 | Mgi Jnum | J:307961 |
| Mgi Id | MGI:6727226 | Doi | 10.4049/jimmunol.2001253 |
| Citation | Chen X, et al. (2021) OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9. J Immunol 206(8):1832-1843 |
| abstractText | CARD9 is an essential adaptor protein in antifungal innate immunity mediated by C-type lectin receptors. The activity of CARD9 is critically regulated by ubiquitination; however, the deubiquitinases involved in CARD9 regulation remain incompletely understood. In this study, we identified ovarian tumor deubiquitinase 1 (OTUD1) as an essential regulator of CARD9. OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-kappaB and MAPK pathway. OTUD1 deficiency impaired CARD9-mediated signaling and inhibited the proinflammatory cytokine production following fungal stimulation. Importantly, Otud1 (-/-) mice were more susceptible to fungal infection than wild-type mice in vivo. Collectively, our results identify OTUD1 as an essential regulatory component for the CARD9 signaling pathway and antifungal innate immunity through deubiquitinating CARD9. |
