| Primary Identifier | MGI:6887861 | Allele Type | Targeted |
| Attribute String | Conditional ready, Hypomorph | Gene | Tjp1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The FRT flanked LacZ-neo-cassette and a loxP replaced a portion of the intron between exons 2 and 3 of the Tjp1 gene. A second loxP site was inserted into the intron between exon 3 and 4, leaving the exon 3 flanked by a pair of loxP. The allele is a hypomorph of ZO-1 isoform resulting in a significant reduction in Tjp1 mRNA levels in the heterozygous mice. |
