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Allele : Nlrp3<em1Bfpy> NLR family, pyrin domain containing 3; endonuclease-mediated mutation 1, Benedicte F Py
Primary Identifier  MGI:7254890 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Nlrp3
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  Using a crRNA (UCUGAUUCCAAAGUCCCCCAGUUUUAGAGCUAUGCUGUUUUG) and an ssODN template (TGTCCCATCAATGCTGCTTCGACATCTCCTCTGTCCTGAGCAGCAGCCAGAAGCTGGTGGAGCTGGACCTCgaTGACAATGCaCTGGGGGACTTTGGAATtcGATTGCTGTGTGTGGGACTGAAGCACCTGCTCTGCA) with CRISPR/Cas9 technology, serine codon 803 (AGT) was changed to aspartic acid (GAT) (p.S803D). This mutation is phosphomimetic for residue 803.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Nlrp3<S803D>,
  • Nlrp3<S803D>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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