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Allele : **Gt(ROSA)26Sor<em3(Gsdmd*)Cya>** gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 3, Cyagen Biosciences

Primary Identifier	MGI:7432801	Allele Type	Endonuclease-mediated
Attribute String	Conditional ready, Epitope tag, Inserted expressed sequence	Gene	Gt(ROSA)26Sor
Strain of Origin	C57BL/6	Is Recombinase	false
Is Wild Type	false

molecularNote

Using CRISPR-CAS9 technology, 3ÃFlag-GSDMD-N fragment with LoxP-flanked stop cassette was inserted into the Gt(ROSA)26Sor locus.

mutations:
Insertion

synonyms:
GSDMD-N<LSL>,
GSDMD-N<LSL>

earliestPublication:
Hu Y, et al. (2022) The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11. Proc Natl Acad Sci U S A 119(45):e2210809119

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

Trail: Allele

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Allele : Gt(ROSA)26Sor<em3(Gsdmd*)Cya> gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 3, Cyagen Biosciences

External Links

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

Allele : **Gt(ROSA)26Sor<em3(Gsdmd*)Cya>** gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 3, Cyagen Biosciences