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Allele : Mlh1<em5Jcs> mutL homolog 1; endonuclease-mediated mutation 5, John C Schimenti
Primary Identifier  MGI:7276206 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Mlh1
Strain of Origin  FVB/NJ x B6(Cg)-Tyr<c-2J>/J Is Recombinase  false
Is Wild Type  false
molecularNote  Using an sgRNA (targeting GCACATTGAGAGCAAGCTGC) and an ssODN template (AAGCACGAAGTTCACTTTCTGCACGAGGAGAGCATTCTGCAGCGTGCGCAGCAGCACATTGAGAGCAAGCTCCTCGGCTCCAATTCCTCCAGGATGTATTTCACCCAG) with CRISPR/Cas9 technology, valine codon 326 (GTG) was changed to alanine (GCG) (c.977T>C, p.V326A).
  • mutations:
  • Single point mutation
  • synonyms:
  • Mlh1<V326A>,
  • Mlh1<V326A>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories





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