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Allele : Rr152<em1.1Cog> regulatory region 152; endonuclease-mediated mutation 1.1, Michel Cogne
Primary Identifier  MGI:7711348 Allele Type  Endonuclease-mediated
Attribute String  Modified regulatory region Gene  Rr152
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  The entire 30.3 kb 3'RR Igh super-enhancer was replaced with a 2.1 kb region comprising only the four core enhancers (hs3a (Rr154), hs1.2 (Rr153), hs3b (Rr155) and hs4 (Rr156) and a loxP site flanked neomycin resistance gene cassette using sgRNAs with CRISPR/Cas9 technology. The neo cassette was removed through subsequent Cre-mediated recombination.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • c3'RR,
  • c3'RR
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1 Feature

Trail: Allele

Genome

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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