| First Author | Tanno N | Year | 2022 |
| Journal | iScience | Volume | 25 |
| Issue | 4 | Pages | 104008 |
| PubMed ID | 35310947 | Mgi Jnum | J:322322 |
| Mgi Id | MGI:7257557 | Doi | 10.1016/j.isci.2022.104008 |
| Citation | Tanno N, et al. (2022) FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis. iScience 25(4):104008 |
| abstractText | Meiotic prophase I is a prolonged G2 phase that ensures the completion of numerous meiosis-specific chromosome events. During meiotic prophase I, homologous chromosomes undergo synapsis to facilitate meiotic recombination yielding crossovers. It remains largely elusive how homolog synapsis is temporally maintained and destabilized during meiotic prophase I. Here we show that FBXO47 is the stabilizer of the synaptonemal complex during male meiotic prophase I. Disruption of FBXO47 shows severe impact on homologous chromosome synapsis, meiotic recombination, and XY body formation, leading to male infertility. Notably, in the absence of FBXO47, although once homologous chromosomes are synapsed, the synaptonemal complex is precociously disassembled before progressing beyond pachytene. Remarkably, Fbxo47 KO spermatocytes remain in an earlier stage of meiotic prophase I and lack crossovers, despite apparently exhibiting diplotene-like chromosome morphology. We propose that FBXO47 plays a crucial role in preventing the synaptonemal complex from premature disassembly during cell cycle progression of meiotic prophase I. |
