| First Author | Zhang J | Year | 2013 |
| Journal | CNS Neurosci Ther | Volume | 19 |
| Issue | 12 | Pages | 937-44 |
| PubMed ID | 24165567 | Mgi Jnum | J:323016 |
| Mgi Id | MGI:6884024 | Doi | 10.1111/cns.12191 |
| Citation | Zhang J, et al. (2013) Glia protein aquaporin-4 regulates aversive motivation of spatial memory in Morris water maze. CNS Neurosci Ther 19(12):937-44 |
| abstractText | AIMS: Although extensive investigation has revealed that an astrocyte-specific protein aquaporin-4 (AQP4) participates in regulating synaptic plasticity and memory, a functional relationship between AQP4 and learning processing has not been clearly established. This study was designed to test our hypothesis that AQP4 modulates the aversive motivation in Morris water maze (MWM). METHODS AND RESULTS: Using hidden platform training, we observed that AQP4 KO mice significantly decreased their swimming velocity compared with wild-type (WT) mice. To test for a relationship between velocities and escape motivation, we removed the platform and subjected a new group of mice similar to the session of hidden platform training. We found that KO mice exhibited a gradual reduction in swimming velocity, while WT mice did not alter their velocity. In the subsequent probe trial, KO mice after no platform training significantly decreased their mean velocity compared with those KO mice after hide platform training. However, all of KO mice were not impaired in their ability to locate a visible, cued escape platform. CONCLUSIONS: Our findings, along with a previous report that AQP4 regulates memory consolidation, implicate a novel role for this glial protein in modulating the aversive motivation in spatial learning paradigm. |
