| First Author | Asami M | Year | 2021 |
| Journal | FEBS Lett | Volume | 595 |
| Issue | 9 | Pages | 1313-1321 |
| PubMed ID | 33599293 | Mgi Jnum | J:325757 |
| Mgi Id | MGI:6729783 | Doi | 10.1002/1873-3468.14059 |
| Citation | Asami M, et al. (2021) Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase eta-knockout mouse brain. FEBS Lett 595(9):1313-1321 |
| abstractText | The molecular mechanisms generating the mania-like abnormal behaviors caused by diacylglycerol (DG) kinase (DGK) eta deficiency remain unclear. Here, we found that DGKeta knockout markedly increased dopamine (DA) levels in the midbrain (DA-producing region, 2.8-fold) and cerebral cortex (DA projection region, 1.2-fold). Moreover, DGKeta deficiency significantly augmented phosphorylated DA transporter (DAT) levels (1.4-fold increase), which induce DA efflux to the synaptic cleft, in the cerebral cortex. Moreover, phosphorylation levels of protein kinase C-beta, which is activated by DG and involved in DAT phosphorylation, were also increased. DAT expressed in Neuro-2a cells recruited DGKeta to the plasma membrane and colocalized with it. These results strongly suggest that dopaminergic hyperfunction caused by DGKeta deficiency in the brain leads to mania-like behaviors. |
