| First Author | Hu J | Year | 2024 |
| Journal | Cell Rep | Volume | 43 |
| Issue | 3 | Pages | 113817 |
| PubMed ID | 38412095 | Mgi Jnum | J:348592 |
| Mgi Id | MGI:7616033 | Doi | 10.1016/j.celrep.2024.113817 |
| Citation | Hu J, et al. (2024) Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice. Cell Rep 43(3):113817 |
| abstractText | Amino acid formula (AAF) is increasingly consumed in infants with cow's milk protein allergy; however, the long-term influences on health are less described. In this study, we established a mouse model by subjecting neonatal mice to an amino acid diet (AAD) to mimic the feeding regimen of infants on AAF. Surprisingly, AAD-fed mice exhibited dysbiotic microbiota and increased neuronal activity in both the intestine and brain, as well as gastrointestinal peristalsis disorders and depressive-like behavior. Furthermore, fecal microbiota transplantation from AAD-fed mice or AAF-fed infants to recipient mice led to elevated neuronal activations and exacerbated depressive-like behaviors compared to that from normal chow-fed mice or cow's-milk-formula-fed infants, respectively. Our findings highlight the necessity to avoid the excessive use of AAF, which may influence the neuronal development and mental health of children. |
