| Primary Identifier | MGI:7378190 | Allele Type | Endonuclease-mediated |
| Attribute String | Hypomorph | Gene | Fga |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology introduced a premature termination codon (ACGT to TTAA change) in exon 5 at residue 271 to generate a truncation mutation in the alphaC region of fibrinogen. Plasma fibrinogen levels in homozygotes are approximately 10% of wild-type levels. The mutant fibrinogen is able to assemble into a mature fibrinogen molecule. Two lines, A and B were generated. Two lines, A and B were generated. This record represents line A. |
