| Primary Identifier | MGI:7290064 | Allele Type | Endonuclease-mediated |
| Attribute String | Inserted expressed sequence, Reporter | Gene | Gt(ROSA)26Sor |
| Inheritance Mode | Not Specified | Strain of Origin | FVB/N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 Humanized sequence mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article. |
