| Primary Identifier | MGI:7328685 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Map4 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology replaced exon 9 with exons containing a serine to alanine substitution at amino acid 667 (S667A), a serine to glutamate substitution at amino acid 737 (S737E), and a serine to glutamate substitution at amino acid 760 (S760E). This knock-in mimics MAP4 hyperphosphorylation at S737 and S760 and unphosphorylated S667 which is seen in tetralogy of Fallot patients. |
