Primary Identifier | MGI:7482682 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Gdf6 |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Tyrosine codon 443 (TAT) was changed to asparagine (AAT) (c.1327T>A p.Y443N) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation is the equivalent of the human p.Tyr444Asn associated with multiple synostoses syndromes (SYNS). |