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Allele : Mgp<em1Murs> matrix Gla protein; endonuclease-mediated mutation 1, Monzur Murshed

Primary Identifier  MGI:7482788 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Mgp
Is Recombinase  false Is Wild Type  false
molecularNote  Serine codons 22 (TCT), 25 (AGC) and 28 (TCC) were targeted for mutation to alanine codons (GCT, GCC, GCT) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This allele contains just the p.S28A (p.S9A in mature protein) mutation. The mutation blocks phosphorylation of the residue in the encoded peptide.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Mgp<S1mut>,
  • Mgp<S1mut>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories

Trail: Allele