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Allele : Unc13a<tm5Bros> unc-13 homolog A; targeted mutation 5, Nils Brose
Primary Identifier  MGI:7484679 Allele Type  Targeted
Gene  Unc13a Transmission  Germline
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  Aspartic acid codons 701 (GAC) and 707 (GAC) in exon 18 were changed to asparagine (AAC) (p.D701N, p.D707N) and an FRT site flanked puromycin resistance gene cassette was inserted into intron 17. The puro cassette was removed through subsequent Flp-mediated recombination. These mutations are located in the C2B domain of the encoded polypeptide and eliminate Ca2+-binding by the C2B domain.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • C2BDN,
  • C2BDN
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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