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Allele : Trp53<tm5.1Glo> transformation related protein 53; targeted mutation 5.1, Guillermina Lozano
Primary Identifier  MGI:7341393 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Trp53
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<+>
Is Recombinase  false Is Wild Type  false
molecularNote  An arginine to histidine substitution (G-to-A at position 515) was introduced at codon 172 (p.R172H) in exon 5. In addition, a loxP site, Trp53 exons 5-11 with a native polyadenylation signal sequence, and FRT site flanked PGK puromycin resistance gene cassette and second loxP site were inserted in intron 4. The PGK puromycin cassette was removed via Flp-mediated recombination.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Trp53<wm-R172H>,
  • Trp53<wm-R172H>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele

0 Driven By

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Trail: Allele




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