| Primary Identifier | MGI:7344056 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence, Reporter, Transactivator | Gene | Tg(Arc-tTA,-EGFP/Capzb*)10Mkyph |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgenic construct contains a tetracycline-controlled transactivator (tTA), followed by a P2A self cleaving peptide, an EGFP/modified Capzb (capping actin protein of muscle Z-line subunit beta) fusion protein, and a polyA sequence under the control of the 7 kb mouse Arc (activity regulated cytoskeletal-associated protein) promoter. EGFP-CapZ retains native C-terminus region that caps F-actin and binds other major binding proteins. The beta2 splice variant is expressed primarily in the brain and less so in striated muscle, which has Capz in the Z disc. |
