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Allele : Cd3e<tm1.1(CD3E)Bms> CD3 antigen, epsilon polypeptide; targeted mutation 1.1, Bristol Myers Squibb
Primary Identifier  MGI:7398576 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Cd3e
Transmission  Germline Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 4 and 5 were replaced with exons engineered to introduce human sequence by replacing the DAENI amino acid sequence with its human counterpart GNEEMGGITQT that encodes for a common epitope recognized by anti-human CD3E antibodies.. A loxP-flanked neomycin cassette was inserted in intron 4. The neomycin cassette was removed via cre-mediated recombination.
  • mutations:
  • Insertion
  • synonyms:
  • hCD3E-epi,
  • hCD3E-epi
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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