| Primary Identifier | MGI:7427813 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Foxl2 |
| Strain of Origin | C57BL/6J x CBA/J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated a C to G change resulting in a cysteine to tryptophan substitution at amino acid 130 (p.C130W). This corresponds to the human p.C134W variant seen in individuals with adult-type granulosa cell tumors. An additional mutation that destroys the Protospacer Adjacent Motif (GCC to GCA) was also introduced. |
