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Allele : Rr231589<em1Smun> regulatory region 231589; endonuclease-mediated mutation 1, Stefan Mundlos

Primary Identifier	MGI:7407307	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr231589
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

The CTCF-binding site in the Kcnj topologically associated domain (TAD) was targeted with an sgRNA (targeting ATGTGATCTCTTTCGCCCTC) using CRISPR/Cas9 technology, resulting in its deletion.

mutations:
Intergenic deletion

synonyms:
deltaCKc,
deltaCKc

earliestPublication:
Despang A, et al. (2019) Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture. Nat Genet 51(8):1263-1271

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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