| Primary Identifier | MGI:7411298 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Slc39a8 |
| Transmission | Germline | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An alanine to threonine substitution at amino acid 393 (p.A393T) was introduced in exon 8 along with an FRT-flanked neomycin resistance cassette 290 bp downstream of exon 8. The neomycin resistance cassette was removed via flp-mediated recombination. The A393T corresponds to human A391T missense variant that is associated with a variety of traits ranging from Parkinsonâs disease and neuropsychiatric disease to cardiovascular and metabolic diseases and Crohnâs disease. |
