Primary Identifier | MGI:7431278 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Hnf1aosc |
Transmission | Germline | Strain of Origin | C57BL/6N |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A STOP cassette (3x SV40 pol(A) signal sequence) and an FRT site flanked neomycin resistance gene cassette were inserted downstream of Hnf1aos1 and Hnf1aos2 promoter/1st exon (inside Hnf1a intron 1). The neo cassette was removed through subsequent flp-mediated recombination. The insertion prematurely terminates transcription of Hnf1aos1 and Hnf1aos2. |