Primary Identifier | MGI:7464147 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Per1-Kcnma1*R207Q)#Alme |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The transgene contains the following elements: a 6,756 bp DNA fragment containing the putative Per1 promoter sequence and the 5'-untranslated region, which encompasses exon 1 and part of exon 2, a modified Kcnma1 cDNA where arginine codon 207 was changed to glutamine (p.R207Q), and hemoglobin beta poly(A) signal sequences. This is a fast-activating gain-of-function mutation. |