| Primary Identifier | MGI:7486152 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Tmem106b |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated an CT to GC change resulting in a threonine to serine substitution at amino acid 186 (p.T186S) in exon 6. Additional silent mutations were introduced to suppress further Cas9 cleavage activity. This variant is a modifier of disease risk in frontotemporal lobar degeneration patients with progranulin mutations and is a protective allele. |
