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Allele : Mtor<em1Dcf> mechanistic target of rapamycin kinase; endonuclease-mediated mutation 1, Diane C Fingar
Primary Identifier  MGI:7466519 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Mtor
Is Recombinase  false Is Wild Type  false
molecularNote  Serine codon 2159 (TCT) in exon 46 was changed to alanine (GCT) (p.S2159A) using two sgRNAs (targeting CACCGTGGTTGGGGTCGTATGTTCC and AAACGGAACATACGACCCCAACCAC) and an ssODN template (GTTCAAAGCTCACATCCCTGGAGCTGCAGTATGTGTCCCCCAAACTTCTGATGTGCCGAGACCTTGAGTTGGCTGTGCCCGGGACATATGACCCAAACCAGCCAATCATTCGCATTCAATCCATAGCCCCGGCTTTGCAAGTCATCACATCCAAGCAGAGGCCTCGGAAGCTGACTCTGA) with CRISPR/Cas9 technology. This mutation prevents phosphorylation of the residue.
  • mutations:
  • Single point mutation
  • synonyms:
  • mTOR<A>,
  • mTOR<A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

3 Publication categories

Trail: Allele




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