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Allele : Kcnt1<em1Nju> potassium channel, subfamily T, member 1; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
Primary Identifier  MGI:7449379 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Kcnt1
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  Tyrosine codon 777 (TAT) in exon 21 was changed to histidine (CAT) (p.Y777H) using an sgRNA and an ssODN template with CRISPR/Cas9 techology. This is a gain-of-function mutation that increases the sodium channel's sensitivity to sodium.
  • mutations:
  • Single point mutation
  • synonyms:
  • Slack-Y777H,
  • Slack-Y777H
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