Primary Identifier | MGI:7465152 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Ank3 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Tryptophan codon 1988 (TGG) in exon 37 was changed to arginine (CGG) (p.W1988R). This mutation is the equivalent of the human p.W1989R mutation found in some bipolar disorder (BD) patients. A loxP site flanked neomycin resistance gene cassette that was inserted into an intron was removed through subsequent Cre-mediated recombination. |