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Allele : Gt(ROSA)26Sor<tm1(tetO-ATP1A3*D591V,-EGFP)Bcgen> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Biocytogen LLC
Primary Identifier  MGI:7449315 Allele Type  Targeted
Attribute String  Conditional ready, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector inserted a CAG promoter, loxP site, FRT-flanked neo-STOP cassette, Tet-responsive element 3G (tetO), loxP site, ATP1A3 cDNA containing an aspartate to valine substitution at amino acid 591 (p.D591V; c.1772A>T), IRES, EGFP, WPRE, and polyA into the locus. The p.D591V missense mutation is a novel variant identified in a family with cone-rod dystrophy.
  • mutations:
  • Insertion
  • synonyms:
  • LSL-ATP1A3<D591V>,
  • LSL-ATP1A3<D591V>
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