| Primary Identifier | MGI:7468713 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Ace2 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated a histidine to lysine substitution at amino acid 353 (p.H353K) in exon 9. K353 is a residue at the core of the ACE2-RBD interaction in humans which has been shown to allow replication of the original SARS coronavirus in mouse cells. |
