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Allele : Twist1<em1Wdf> twist basic helix-loop-helix transcription factor 1; endonuclease-mediated mutation 1, Walid D Fakhouri
Primary Identifier  MGI:7469499 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Twist1
Is Recombinase  false Is Wild Type  false
molecularNote  Serine codon 18 (AGC) was changed to isoleucine (ATC) (p.S18I) and serine codon 20 (AGC) to alanine (GCT) (p.S20A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. These mutations prevent phosphorylation of the highly conserved residues.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Twist1<S18I;20A>,
  • Twist1<S18I;20A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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