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Allele : Twist1<em4Wdf> twist basic helix-loop-helix transcription factor 1; endonuclease-mediated mutation 4, Walid D Fakhouri
Primary Identifier  MGI:7469502 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Twist1
Is Recombinase  false Is Wild Type  false
molecularNote  Threonine codon 125 (ACG) was changed to alanine (GCG) (p.T125A) and serine codon 127 (TCG) to alanine (GCG) (p.S127A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. These mutations of the highly conserved residues in the helix 1 domain prevent phosphorylation of the residues.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Twist1<T121;S123A>,
  • Twist1<T121;S123A>
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Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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