| First Author | Uchida Y | Year | 2020 |
| Journal | Biochem Biophys Rep | Volume | 23 |
| Pages | 100791 | PubMed ID | 32793817 |
| Mgi Jnum | J:336137 | Mgi Id | MGI:7486747 |
| Doi | 10.1016/j.bbrep.2020.100791 | Citation | Uchida Y, et al. (2020) CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice. Biochem Biophys Rep 23:100791 |
| abstractText | Sepsis is defined as a life-threatening multiorgan dysfunction caused by dysregulated inflammatory response to infection. It remains the primary cause of death from infection if not diagnosed and treated promptly. Therefore, a better understanding of the mechanism for resolving inflammation is needed. Monocytes and macrophages play a pivotal role not only in the induction but also in the suppression of inflammation. However, a tissue-resident macrophage subset that regulates a hyperinflammatory state during sepsis has not been explored. Here we show that CD204+ monocytes and/or macrophages rescued mice from endotoxin-induced septic shock. Serum and tissue proinflammatory cytokine levels were significantly upregulated in the absence of these cells. This study provided evidence that CD204+ monocytes and/or macrophages ameliorate septic shock by suppressing proinflammatory cytokine production. |
