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Allele : Lmna<em1Iko> lamin A; endonuclease-mediated mutation 1, Issei Komuro
Primary Identifier  MGI:7471418 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Lmna
Strain of Origin  (C57BL/6 x DBA/2)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/FokI-dCAs9 technology generated an A to G change resulting in a glutamine to arginine substitution at amino acid 353. This mutation was identified in a large familial cohort with dilated cardiomyopathy.
  • mutations:
  • Single point mutation
  • synonyms:
  • Lmna<Q353R>,
  • Lmna<Q353R>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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