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Allele : Tg(Camk2a-cre/ERT2/Hif1a)#Heh transgene insertion, Hannelore Ehrenreich
Primary Identifier  MGI:7481236 Allele Type  Transgenic
Attribute String  Inducible, Recombinase Gene  Tg(Camk2a-cre/ERT2/Hif1a)#Heh
Strain of Origin  Not Specified Induced With  tamoxifen and hypoxia
Is Recombinase  true Is Wild Type  false
molecularNote  The transgene containing the murine Camk2a promoter drives expression of the tamoxifen-inducible cre recombinase gene (cre/ERT2) fused with the oxygen-dependent degradation (ODD) domain of Hif1a. This transgene is responsive to hypoxia. Under normoxic conditions, the ODD is hydroxylated by prolylhydroxylases, which tag HIF-1α upon binding of Von Hippel-Lindau (VHL) protein for proteasomal degradation. Hypoxic conditions lead to the inactivation of these enzymes and thus stabilization of HIF-1α, allowing it to accumulate in the nucleus and activate the transcription of its target genes. The pound symbol (#) is used when no line is specified and/or lines are pooled.
  • mutations:
  • Insertion
  • synonyms:
  • CamkIIa-CreERT2-ODD,
  • CamkIIa-CreERT2-ODD
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Trail: Allele

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Trail: Allele




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