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Allele : Nf1<em2Gtm> neurofibromin 1; endonuclease-mediated mutation 2, David H Gutmann
Primary Identifier  MGI:7488392 Allele Type  Endonuclease-mediated
Gene  Nf1 Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  Arginine codon 1278 (CGA) was changed to proline (CCA) (p.R1278P) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human c.3827G>C, p.Arg1276Pro mutation associated with neurofibromatosis 1 (NF1).
  • mutations:
  • Single point mutation
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1 Feature

Trail: Allele

Genome

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Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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