| Primary Identifier | MGI:7506564 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Dnmt1 |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Tyrosine codon 501 (TAT) was changed to cysteine (TGT) (p.Y501C) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation mimics the human p.Y495C mutation associated with HSAN1E (hereditary sensory and autonomic neuropathy type 1E with dementia and hearing loss). |
