Primary Identifier | MGI:7490020 | Allele Type | Endonuclease-mediated |
Attribute String | Not Specified | Gene | Sting1 |
Strain of Origin | C57BL/6NCrl | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A S365A (nucleotide change AGT to GCT) mutation is introduced to a phosphorylation site in exon 8. A silent CCA to CCT mutation at amino acid 360 was introduced for genotyping purposes and to prevent Cas9/gRNA from targeting already edited sequences. The mutation disrupts IRF3 binding. |