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Allele : Sting1<em1Zjc> stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Zhijian Chen

Primary Identifier  MGI:7490020 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Sting1
Strain of Origin  C57BL/6NCrl Is Recombinase  false
Is Wild Type  false
molecularNote  A S365A (nucleotide change AGT to GCT) mutation is introduced to a phosphorylation site in exon 8. A silent CCA to CCT mutation at amino acid 360 was introduced for genotyping purposes and to prevent Cas9/gRNA from targeting already edited sequences. The mutation disrupts IRF3 binding.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • STING-S365A,
  • STING-S365A
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

2 Publication categories

Trail: Allele