| Primary Identifier | MGI:7507636 | Allele Type | Endonuclease-mediated |
| Gene | Trem2 | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated a CACAGCACC to ATCCCCGAC change, resulting in the substitution of amino acids histidine 157, serine 158 and threonine 159 (HST) to isoleucine, proline, and aspartate (IPD). IPD are the least-preferred amino acids for the sub-site biding of ADAM10/17 and this change is expected to reduce TREM2 proteolytic cleavage. |
