| First Author | Smole U | Year | 2020 |
| Journal | Nat Immunol | Volume | 21 |
| Issue | 7 | Pages | 756-765 |
| PubMed ID | 32572240 | Mgi Jnum | J:298918 |
| Mgi Id | MGI:6472533 | Doi | 10.1038/s41590-020-0698-1 |
| Citation | Smole U, et al. (2020) Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity. Nat Immunol 21(7):756-765 |
| abstractText | The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), that promotes pulmonary type 2 immunity. Mechanistically, SAA1 interacted directly with allergenic mite FABPs (Der p 13 and Blo t 13). The interaction between mite FABPs and SAA1 activated the SAA1-binding receptor, formyl peptide receptor 2 (FPR2), which drove the epithelial release of the type-2-promoting cytokine interleukin (IL)-33 in a SAA1-dependent manner. Importantly, the SAA1-FPR2-IL-33 axis was upregulated in nasal epithelial cells from patients with chronic rhinosinusitis. These findings identify an unrecognized role for SAA1 as a soluble pattern recognition receptor for conserved FABPs found in common mite allergens that initiate type 2 immunity at mucosal surfaces. |
